A UCLA Samueli-led team has developed a specially adapted 3D printer to build therapeutic biomaterials from multiple materials. The advance could be a step toward on-demand printing of complex artificial tissues for use in transplants and other surgeries.
“Tissues are wonderfully complex structures, so to engineer artificial versions of them that function properly, we have to recreate their complexity,” said Ali Khademhosseini, who led the study and is UCLA’s Levi James Knight, Jr., Professor of Engineering at the UCLA Samueli School of Engineering. “Our new approach offers a way to build complex biocompatible structures made from different materials.”
The technique uses a light-based process called stereolithography, and it takes advantage of a customized 3D printer designed by Khademhosseini that has two key components. The first is a custom-built microfluidic chip — a small, flat platform similar in size to a computer chip — with multiple inlets that each “prints” a different material. The other component is a digital micromirror, an array of more than a million tiny mirrors that each moves independently.